oligoribonuclease (nanoRNase), 3,5-bisphosphate nucleotidase
function
degradation of RNA oligonucleotides
product
oligoribonuclease (nanoRNase), 3,5-bisphosphate nucleotidase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.1|Exoribonucleases]Gene
Coordinates
2,995,908 → 2,996,849
Phenotypes of a mutant
The mutant requires cysteine [Pubmed|17586819]inactivation of ''[gene|4C630B61249F8F2369E9BFE8A49885D3225DE7B6|nrnA]'' reduces sporulation efficiency to 5% that of wild type cells; delayed entry into sporulation, reduced SigmaG activity, and production of small forespores [Pubmed|26735940]The protein
Catalyzed reaction/ biological activity
Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate (according to Swiss-Prot)oligoribonuclease (nanoRNAse), 3',5'-bisphosphate nucleotidase [Pubmed|17586819]hydrolyze oligo(deoxy)ribonucleotides in a 5'-3' direction [Pubmed|21087930]Structure
[PDB|3DEV] (from S. haemolyticus, 49% identity)[SW|Localization]
Cytoplasm (Homogeneous) [Pubmed|16479537]Expression and Regulation
Operons
genes
[gene|4C630B61249F8F2369E9BFE8A49885D3225DE7B6|nrnA]
description
[Pubmed|9387221]
Biological materials
Mutant
MGNA-A151 (ytqI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/151 NBRP B. subtilis, Japan]GP2155 (''[gene|4C630B61249F8F2369E9BFE8A49885D3225DE7B6|nrnA]''::''aphA3''), available in [SW|Jörg Stülke]'s labReferences
17586819,9387221,16479537,19429620,19553197,21087930,22102036,26691161,21768284,24013631,26735940,27834680 
